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Briefings in Bioinformatics, Volume 27
Volume 27, Number 1, 2026
- Yu Zhang

, Ming Li, David M. Haas, C. Noel Bairey Merz, Tsegaselassie Workalemahu, Kelli Ryckman, Janet M. Catov, Lisa D. Levine, Alexa Freedman
, George R. Saade
, Jiaqi Hu
, Hongyu Zhao
, Xihao Li, Nianjun Liu
, Qi Yan:
A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk. - Wenli Zhai, Lingyun Sun, Wenwei Fang, Yidan Dong, Chunxiao Cheng, Yuanjiao Liu, Yuan Zhou, Jiadong Ji

, Lang Wu
, An Pan
, Eric R. Gamazon
, Xiong-Fei Pan
, Dan Zhou
:
Cross-ancestry information transfer framework improves protein abundance prediction and protein-trait association identification. - Lena Maria Hackl

, Fabian Neuhaus, Sabine Ameling, Uwe Völker, Jan Baumbach
, Olga Tsoy
:
Detection of alternative splicing: deep sequencing or deep learning? - Yonglin Peng, Xinhua Liu, Jun Wu

, Sang Lin, Shengxuan Zhan, Hua Li, Ju Wang
, Xiaodong Zhao
:
EpiXFormer: a cross-attention neural network for predicting cell type-specific transcription factor binding sites. - Minrui Xu, Manman Lu, Peng Liu, Siwen Zhang, Lanming Chen, Qi Liu

, Yong Lin, Lu Xie
:
ProTCR: a protein language model-driven framework for decoding TCR-antigen recognition toward precision immunotherapies. - Yosra Berrouayel

, Luis del Peso
:
Enhancing TFEA.ChIP with ENCODE regulatory maps for generalizable transcription factor enrichment. - Chenjie Feng, Xiaowen Sun

, Xintao Song, Lei Bao
, Weikang Gong, Renmin Han
:
DeepRMSF: a deep learning-based automated approach for predicting atomic-level flexibility in RNA structure. - Ruhai Chen

, Jiekai Chen
, Lingling Shi, Jiangping He:
iceDP: identifying inter-chromatin engagement via density peaks clustering algorithm. - Youshu Cheng

, Chen Lin
, Hongyu Li, Ke Xu, Hongyu Zhao
:
UBD: incorporating uncertainty in cell type proportion estimates from bulk samples to infer cell-type-specific profiles. - Dong Chen

, Yuquan Wang, Dapeng Shi, Yunlong Cao, Yue-Qing Hu
:
MACFIV: a novel framework for nonlinear causal inference in the body mass index-hypertension relationship with many weak and pleiotropic genetic instruments. - Wonkyeong Jang

, Woong-Hee Shin
:
CoBRA: compound binding site prediction using RNA language model. - Zhen Tian

, Xiaojiao Wei, Zhengzheng Lou, Zhixia Teng
, Shouli Fu:
Adaptive multi-view information bottleneck for multi-omics data clustering. - Alexander Partin

, Priyanka Vasanthakumari
, Oleksandr Narykov
, Andreas Wilke
, Natasha Koussa
, Sara E. Jones
, Yitan Zhu
, Jamie C. Overbeek
, Rajeev Jain, Gayara Demini Fernando
, Cesar Sanchez-Villalobos, Cristina Garcia-Cardona
, Jamaludin Mohd-Yusof
, Nicholas Chia
, Justin M. Wozniak
, Souparno Ghosh, Ranadip Pal
, Thomas S. Brettin, M. Ryan Weil, Rick L. Stevens
:
Benchmarking community drug response prediction models: datasets, models, tools, and metrics for cross-dataset generalization analysis. - Sang-Pil Cho, Young-Rae Cho

:
GRAFT: a graph-aware fusion transformer for cancer driver gene prediction. - Bingyan Wang

, Heng Hu
, Runtian Gao
, Guohua Wang, Tao Jiang
:
GFSeeker: a splicing-graph-based approach for accurate gene fusion detection from long-read RNA sequencing data. - Can Shi

, Yumei Li, Jing Guo, Qiuling Chen, Tingting Cao, Sha Liao, Ao Chen, Mei Li, Ying Zhang
:
CSRefiner: a lightweight framework for fine-tuning cell segmentation models with small datasets. - Jiayi Li, Shenglun Chen, Zhixing Wu, Haozhe Wang, Rong Xia

, Jia Meng
, Yuxin Zhang
:
CircRM: profiling circular RNA modifications from nanopore direct RNA sequencing. - Bosheng Song

, Jiayi Zhang, Ying Liu, Yuansheng Liu
, Jing Jiang, Sisi Yuan, Xia Zhen, Yiping Liu
:
A systematic review of molecular representation learning foundation models. - Inas Bosch

, Barbara Gravel
, Alexandre Renaux
, Ann Nowé, Maris Laan
, Tom Lenaerts
:
Benchmarking knowledge graph embedding models for the prediction of oligogenic combinations. - Xunuo Zhu, Wenyi Zhao

, Siqi Wang, Jingwen Yang, Jingqi Zhou, Binbin Zhou, Ji Cao
, Bo Yang, Zhan Zhou
, Xun Gu
:
Identification of cancer mini-drivers by deciphering selective landscape in the cancer genome.
Volume 27, Number 2, 2026
- Zhihao Wang, Sheng Wang, Jingjing Guo

, Yuguang Mu, Xiangdong Liu, Liangzhen Zheng
, Weifeng Li:
Could statistical potential models achieve comparable or better performance than deep learning models? - Vincenzo Laveglia, Cosimo Ciofalo, Enrico Morelli, Claudia Andreini, Antonio Rosato

:
Master of Metals2: a graph neural network based architecture for the prediction of zinc binding sites in protein structures. - Jing Wang

, Junfeng Xia
, Yansen Su
, Chun-Hou Zheng:
scSCCNIA: similarity matrix based contrastive clustering with neighbor information aggregation for single-cell RNA sequencing data. - Publisher's Note: Addendum to Volume 26, Issue Supplement 1, December 2025, International Conference on Genome Informatics ISCB-Asia 2025 Abstract Book.

- Sandeep Acharya

, Vaha Akbary Moghaddam, Wooseok J. Jung
, Yu S. Kang, Shu Liao, Michael A. Province
, Michael R. Brent
:
Finding Significant Hits in Networks: a network-based tool for analyzing gene-level P -values to identify significant genes missed by standard methods. - Lotta Eriksson

, Eszter Lakatos
:
Sensitive detection of copy number alterations in low-pass liquid biopsy sequencing data. - Cheng Zhong, Siqi Jiang

, Zhi Wei
:
Integrating feature selection with unsupervised deep embedding for clustering single-cell RNA-seq data. - Jingzhan Lu

, Johan Hilge Thygesen, Robin N. Beaumont
, Michael N. Weedon, Harry D. Green
:
Impact of control selection strategies on GWAS results: a study of prostate cancer in the UK Biobank. - Ashitha Washington, Ravindra Kumar:

Machine Learning Driven Discovery of Ribosomal Biomarkers in PCOS. 2- - Shuang-Hao Yang

, Hua He, Shuyu Hou, Tuanfeng Yang, Zehao Yin, Hong-Yu Zhang
, Weiyue Gu:
ML-ExonCNV: a robust XGBoost multi-expert ensemble framework for rare exon CNV detection in whole-exome sequencing data. - Mingqing Liu

, Jinhui Xu, Ji Liu:
A progressive fine-tuning framework with dynamic parameter selection for low-resource peptide-GPCR interaction prediction. - Yang Deng

, Jinhao Que, Guangfu Xue, Yideng Cai, Wenyi Yang, Yilin Wang, Yi Hui, Zuxiang Wang, Yi Lin
, Wenyang Zhou
, Zhaochun Xu, Qinghua Jiang, Haoxiu Sun:
AI-driven computational methods and benchmarking for T-cell antigen identification. - He Wang, Yikun Zhang, Jie Chen, Jian Zhan

, Yaoqi Zhou
:
Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning. - Qiong Chen, Boliang Zhang, Chen Peng, Jiajun Huang, Zhen Liu, Xiaotao Shen, Chao Jiang

:
Kun-peng enables scalable and accurate pan-domain metagenomic classification. - Daohong Gong

, Xiaowei Xie, Jianxin Tang, Shiliang Li, Honglin Li:
Transformer-based multidimensional feature fusion for accurate prediction of lipid nanoparticles transfection efficiency. - Lingyu Li

, Wai-Ki Ching, Zhi-Ping Liu
:
Prognostic biomarker discovery via a connected network-constrained Cox proportional hazards model. 1- - Sunil Nagpal

:
Supervisory signals are intriguingly high in even simple features for predicting anticancer effect of antibody drug conjugates. - Paramita Roy

, Dibakar Roy
, Sudipto Bhattacharjee
, Abhirupa Ghosh
, Sudipto Saha
:
MDPD reveals specific microbial signatures in human pulmonary diseases. - Huasen Jiang, Xiaoyu Huang, Xiangpeng Bi, Wenjian Ma

, Haibo Ni, Zhiqiang Wei, Pin Sun, Henggui Zhang, Shugang Zhang
:
Artificial intelligence-enabled multi-scale virtual cell: perspective, challenges, and opportunities. - Yiyi Yu, Jiyuan Yang, Ping-An He

, Xiaoqi Zheng
:
Castl: robust identification of spatially variable genes in spatial transcriptomics via an ensemble-based framework. - Yongli Peng, Yujing Deng, Menghan Liu, Zhiyuan Liu, Ya-Hui Li, Xiang-Yu Zhao, Dong Xing

, Jinzhu Jia
, Hao Ge:
scDIAGRAM: detecting chromatin compartments from individual single-cell Hi-C matrix without imputation or reference features. - Lihui Jin

, Zhenyuan Han, Rebecca Hannah, Hongyu Shao, Junxin Huang, Shiying Wang, Weibin Zhang, Jiang Lin, Kun Sun, Yu Yu:
Computational identification of lineage-committed precursors in mammalian organogenesis reveals a novel hematopoietic enhancer regulating Bhlhe41 expression. - Bui Tien Thanh

, Yoichi Kurumida, Kaito Kobayashi
, Michiaki Hamada
, Tomoshi Kameda
:
Differentiation of RNA-protein docking structures through molecular dynamics simulation and machine learning methods. - M. D. Youshuf Khan Rakib

, Muhammad Habibulla Alamin
, Jiamu Li
, Sheikh Sohan Mamun
, Kaleb Amsalu Gobena
, Shengbing Ren
:
KANPM-DTA: improving drug-target affinity prediction with Kolmogorov-Arnold networks and pretrained models. - Sudipto Baul, Naima Ahmed Fahmi, Guangyu Wang, Hao Zheng, Ahmed Louri, Jeongsik Yong

, Wei Zhang
:
EpGAT: integrating epigenetics and 3D genome structure to predict alternative splicing and polyadenylation. - Chenyu Ren, Daihai He

, Jian Huang
:
De novo functional protein sequence generation: overcoming data scarcity through regeneration and large language models. - Alexa H. Beachum, Xue Xiao, Yuansheng Zhou, Qiwei Li

, Guanghua Xiao
, Lin Xu
:
Advances in predicting omics profiles from imaging data. - Chuyun Zhang, Kei Hang Katie Chan:

An integrative multi-omics framework for decoding microglial ecosystems in Alzheimer's disease. 3- - Juntao Deng

, Miao Gu, Pengyan Zhang, Tao Liu, Guansong Hu, Mingyu Dong, Yabin Zhang, Yizhen Song, Yunfan Zhang, Min Liu
, Junzhang Tian, Weibin Cheng
:
MutPPI+: a multimodal framework for predicting mutation effects on protein-protein interactions via mutation-path-based data augmentation. - Syed Mohammed Khalid

, Tom Wölker, Leidy-Alejandra G. Molano, Simon Graf, Andreas Keller:
Benchmarking large language models for pathogen-disease classification in post-acute infection syndromes. - Shuo Zhang, Jike Qi, Yuchen Jiang, Hua Lin, Xinyi Wang, Ting Wang, Hongyan Cao

, Ping Zeng
:
An integrative association analysis for complex diseases in underrepresented groups by leveraging the trans-ethnic genetic similarity. - Mawada Elmagboul Abdalla Abakar, Mehad Almagboul Abdalla Abaker, Marco Antoniotti, Alex Graudenzi:

Phylogenetic analysis of TET2 gene variants in Pakistani acute myeloid Leukemia patients. 4- - Yizhou Zeng, Lei Wang, Xueming Liu

:
BioMNEDR: mechanism-guided network embedding for drug repurposing. - Peter T. Nguyen, Maria Zhivagui

:
SigRescueR : a pan-system framework for noise correction and mutational signature identification across sequencing platforms. - Wasif Jalal, Mubasshira Musarrat, Md. Abul Hassan Samee, M. Sohel Rahman:

ORANGE: a machine learning approach for modeling tissue-specific aging from transcriptomic data. - Junlin Xu, Cheng Guo

, Yajie Meng
, Shuting Jin, Changcheng Lu
, Zilong Zhang
, Feifei Cui
, Xiangzheng Fu
, Quan Zou
, Tian Tian, Xiangxiang Zeng
:
A deep adversarial network model for multi-task analysis of single-cell omics data. - Chun Shang, Kevin C. Chan

, Ruhong Zhou
:
Decoding TCR recognition via geometric deep learning of immunological fingerprints.

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